Kaplan USMLE Step 1 2026 (Videos + Quiz + Questions with Answers)

Kaplan USMLE Step 1 2026 (Videos + Quiz + Questions with Answers)

Kaplan USMLE Review | Step 1 Basic Sciences and Organ-System Study

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The Kaplan USMLE Step 1 2026 (Videos + Quiz + Questions with Answers) provides a comprehensive review of the foundational sciences tested on the United States Medical Licensing Examination (USMLE) Step 1.

The official Kaplan Step 1 program describes nearly 1,200 videos, 1,600+ module questions and a Qbank of more than 3,000 questions. These provider figures are given for comparison and do not establish the number of files or questions delivered by this store.

The program allows students to study either by traditional foundational science discipline or through an integrated organ-system approach, making it possible to build a strong basic science foundation while also practicing the way concepts are integrated on the current Step 1 examination.

Major disciplines include Anatomy, Behavioral Sciences, Biochemistry, Immunology, Microbiology, Physiology, Pathology, and Pharmacology, while system-based study covers areas such as cardiovascular, respiratory, renal, gastrointestinal, endocrine, reproductive, nervous system, hematology/oncology, infectious disease, and more.

Course Details

• Course: Kaplan USMLE Step 1 2026
• Provider: Kaplan Medical / Kaplan Test Prep
• Exam: USMLE Step 1
• Publication / Study Year: 2026
• Format Available Here: Videos + Quizzes + Questions with Answers
• Instructional Videos: Nearly 1,200
• Additional Module Quiz Questions: 1,600+
• Step 1 QBank: 3,000+ exam-style questions
• Diagnostic Exam: Included in the official Kaplan curriculum
• Discipline Assessment Exams: 9
• Lecture Notes: Kaplan USMLE Step 1 Lecture Notes
• Study Structure: Discipline-Based + Organ-System-Based
• High-Yield Filtering: Available within Kaplan’s official activity structure
• Primary Focus: Foundational Science, Clinical Integration and Step 1 Board Preparation

Kaplan’s current official Step 1 course confirms nearly 1,200 instructional videos, more than 1,600 quiz questions, a 3,000+ question QBank, a diagnostic examination, nine discipline assessments, and digital Step 1 Lecture Notes.

Official Kaplan Program Components

The following descriptions refer to the provider’s learning program. Inclusion in the MedicalAmboss file package must be checked against its contents and sample.

Nearly 1,200 Instructional Videos

Kaplan’s Step 1 curriculum includes nearly 1,200 educational videos organized into structured learning modules.

The video-based format is designed to help students build foundational understanding before moving into intensive question practice.

Major areas include:

• Anatomy
• Behavioral Sciences
• Biochemistry
• Genetics
• Immunology
• Microbiology
• Physiology
• Pathology
• Pharmacology
• Organ-system integration

1,600+ Additional Quiz Questions

Each Kaplan learning module incorporates:

• Reading assignments
• Pre-quizzes
• Post-quizzes

Together, these provide more than 1,600 additional questions beyond the main QBank.

The pre- and post-question structure helps students assess understanding before and after studying each module.

Kaplan USMLE Step 1 QBank – 3,000+ Questions

The official Kaplan Step 1 QBank contains more than 3,000 exam-style questions.

The QBank is designed to reinforce:

• Foundational science concepts
• Clinical application
• Integrated reasoning
• Patient-centered vignettes
• Diagnostic thinking
• Mechanisms of disease
• Pharmacology
• System-based knowledge

Question practice helps students move from passive content review toward the application-based reasoning expected on the USMLE.

Kaplan USMLE Step 1 Lecture Notes

The curriculum includes access to Kaplan’s USMLE Step 1 Lecture Notes.

Kaplan describes these books as frequently updated, highly illustrated resources containing clinical correlations, connections between disciplines, outline-based explanations, and high-yield summary material.

Major Lecture Notes volumes include:

• Anatomy
• Behavioral Science / Social Sciences
• Biochemistry / Medical Genetics
• Immunology / Microbiology
• Pathology
• Pharmacology
• Physiology

Diagnostic Exam

The Kaplan curriculum includes a diagnostic examination designed to help identify areas of strength and weakness early in preparation.

Students can use diagnostic results to:

• Identify weak disciplines
• Prioritize high-yield topics
• Adjust their study schedule
• Direct additional QBank practice
• Monitor knowledge gaps

This allows the study process to become more individualized.

9 Discipline Assessment Exams

Kaplan includes nine discipline assessment exams to evaluate knowledge across major foundational science subjects.

These assessments provide an additional way to determine whether a student has mastered a discipline before progressing toward broader integrated practice.

Study by Discipline or Organ System

One of the major strengths of the Kaplan Step 1 curriculum is its flexible organization.

Students can study:

By Discipline

Build detailed foundational understanding before integrating material.

or

By Organ System

Connect anatomy, physiology, pathology, pharmacology, microbiology, and other concepts around a single clinical system.

This approach is consistent with the modern USMLE Step 1 blueprint, which integrates foundational sciences across organ systems.

Discipline-Based Review

Anatomy

Learn structural anatomy in a clinically relevant framework.

Important areas include:

• Gross anatomy
• Neuroanatomy
• Musculoskeletal anatomy
• Embryology
• Anatomical relationships
• Clinical correlations

Anatomy knowledge is increasingly integrated into clinical vignettes rather than tested only as isolated structures.

Behavioral Sciences

The Behavioral Sciences curriculum helps students review:

• Biostatistics
• Epidemiology
• Ethics
• Patient communication
• Behavioral medicine
• Health systems
• Population health
• Clinical decision-making

USMLE currently assigns explicit content weighting to both Biostatistics & Epidemiology/Population Health and Communication and Interpersonal Skills.

Biochemistry

Kaplan’s Biochemistry review helps students integrate:

• Metabolic pathways
• Molecular biology
• Genetics
• Enzyme function
• Cellular metabolism
• DNA and RNA
• Gene expression
• Nutritional biochemistry

The emphasis is on understanding mechanisms rather than simply memorizing isolated pathways.

Immunology

The Immunology section explains immune-system mechanisms relevant to both normal physiology and disease.

Topics include:

• Innate immunity
• Adaptive immunity
• Antibodies
• T-cell function
• B-cell function
• Hypersensitivity
• Autoimmunity
• Immunodeficiency
• Vaccination

Microbiology

The Microbiology curriculum organizes clinically important organisms into testable patterns.

Major groups include:

• Bacteria
• Viruses
• Fungi
• Parasites
• Antimicrobial mechanisms
• Host-pathogen interaction

This helps students move beyond simple organism memorization toward clinically integrated infectious disease reasoning.

Physiology

Physiology provides the mechanistic foundation necessary to understand disease.

Major areas include:

• Cardiovascular physiology
• Pulmonary physiology
• Renal physiology
• Gastrointestinal physiology
• Endocrine physiology
• Reproductive physiology
• Neurophysiology
• Acid-base physiology

USMLE continues to assign substantial weight to physiology within Step 1.

Pathology

Pathology is one of the largest and most important disciplines on Step 1.

Kaplan’s pathology content emphasizes:

• Mechanisms of disease
• Cellular injury
• Inflammation
• Neoplasia
• Organ-system pathology
• Histopathology
• Clinical disease patterns

The official USMLE Step 1 blueprint currently lists pathology at approximately 45–55%, noting that individual questions can overlap multiple disciplines.

Pharmacology

The Pharmacology curriculum emphasizes understanding drugs through their mechanisms and clinical applications, rather than relying only on memorization.

Key areas include:

• Pharmacokinetics
• Pharmacodynamics
• Mechanisms of action
• Drug interactions
• Adverse effects
• Therapeutic indications
• Toxicology
• System-specific pharmacology

Organ-System-Based Review

Foundations of Medicine

Provides a framework for concepts that apply across multiple organ systems.

Areas may include:

• Cellular biology
• Genetics
• Immunology
• Pathology
• Pharmacologic principles
• Molecular mechanisms

Nervous System

Integrates:

• Neuroanatomy
• Neurophysiology
• Neuropathology
• Neurology
• Neuropharmacology

This section helps connect structural neuroanatomy with clinical neurologic disease.

Cardiovascular System

Major areas include:

• Hemodynamics
• Cardiac physiology
• Murmurs
• Ischemic heart disease
• Heart failure
• Arrhythmias
• Hypertension
• Cardiovascular pharmacology

The goal is to connect normal cardiovascular physiology with pathology and therapeutic mechanisms.

Respiratory System

The respiratory curriculum integrates:

• Pulmonary physiology
• Ventilation and perfusion
• Acid-base physiology
• Obstructive disease
• Restrictive disease
• Pulmonary pathology
• Respiratory pharmacology

Renal System

The Renal section focuses on commonly challenging topics such as:

• Renal physiology
• Glomerular function
• Tubular transport
• Electrolytes
• Acid-base disorders
• Kidney disease
• Renal pharmacology

Gastrointestinal System

The Gastrointestinal curriculum connects:

• Anatomy
• Physiology
• Digestion
• Absorption
• Pathology
• Liver disease
• Pancreatic disease
• GI pharmacology

Endocrine System

The Endocrine section helps students understand:

• Hormonal physiology
• Feedback mechanisms
• Pituitary disease
• Thyroid disorders
• Adrenal disease
• Diabetes
• Calcium metabolism
• Endocrine pharmacology

Reproductive System

Relevant content includes:

• Male reproductive anatomy
• Female reproductive anatomy
• Reproductive physiology
• Embryology
• Pregnancy
• Reproductive pathology
• Hormonal pharmacology

Musculoskeletal, Skin & Connective Tissue

This system integrates:

• Musculoskeletal anatomy
• Bone physiology
• Muscle disease
• Dermatology
• Rheumatology
• Connective tissue disorders
• Autoimmune disease

Hematology & Oncology

This section focuses on recognizing patterns involving:

• Anemia
• Hemoglobin disorders
• Coagulation
• Leukemia
• Lymphoma
• Cancer biology
• Oncogenes
• Tumor suppressors
• Chemotherapy principles

Immune System

The Immune System curriculum connects basic immunology with clinical disorders.

Major topics include:

• Immunodeficiency
• Hypersensitivity
• Autoimmune disease
• Transplant immunology
• Immune therapies
• Vaccine mechanisms

Infectious Disease

The Infectious Disease section integrates microbiology with clinically relevant diagnosis and treatment.

Students review:

• Pathogen identification
• Disease patterns
• Antimicrobial mechanisms
• Resistance
• Appropriate therapy
• Host response

High-Yield Filter Capability

Kaplan’s current Step 1 course includes an Activity Library that allows students to filter educational content by criteria including organ system and high-yield material.

This can be useful when:

• Dedicated study time is limited
• Weak topics need targeted review
• Students are approaching the examination
• A rapid final review is needed

Integrated Learning

One of the most important features of modern Step 1 preparation is integration.

For example, a cardiovascular question may require understanding of:

• Anatomy
• Physiology
• Pathology
• Pharmacology
• Biochemistry
• Microbiology

rather than testing one isolated discipline.

USMLE officially describes Step 1 as using an integrated content outline organized according to organ systems, with foundational sciences distributed throughout disease processes and clinical scenarios.

Built for Understanding and Retention

The Kaplan curriculum emphasizes concept understanding before repeated question practice.

A practical sequence is:

Learn → Quiz → Identify Weaknesses → Review → Practice QBank → Reassess

This approach helps students develop knowledge that can be applied to new clinical vignettes rather than repeatedly memorizing disconnected facts.

Current USMLE Step 1 Exam Structure – 2026

An important format change took effect on May 14, 2026.

For Step 1 examinations taken on or after that date:

• The exam remains a one-day examination
• Total testing session remains approximately 8 hours
• There are 14 blocks
• Each block is 30 minutes
• Each block contains no more than 20 questions
• Total examination questions remain no more than 280
• Minimum break time is 55 minutes
• Optional tutorial is 5 minutes

This replaced the previous seven 60-minute block structure.

How Step 1 Tests Knowledge

The USMLE states that Step 1 assesses whether students can understand and apply foundational science concepts underlying:

• Health
• Disease
• Mechanisms of disease
• Therapy

Although some questions assess knowledge directly, most require interpretation and application.

Questions can involve:

• Patient-centered clinical vignettes
• Tables
• Graphs
• Microscopic pathology
• Gross pathology
• Clinical reasoning

The official exam uses single-best-answer multiple-choice questions.

Major USMLE Step 1 Disciplines

The official USMLE blueprint includes:

• Pathology
• Physiology
• Nutrition
• Gross Anatomy & Embryology
• Microbiology
• Pharmacology
• Behavioral Sciences
• Biochemistry
• Histology & Cell Biology
• Immunology
• Genetics

Questions are deliberately integrated, and a single question may be classified under multiple disciplines.

Suggested Study Strategy

1. Start With the Diagnostic Exam

Identify your strongest and weakest subjects.

2. Review Weak Disciplines

Use Kaplan videos and Lecture Notes to rebuild foundational understanding.

3. Complete Module Quizzes

Use pre- and post-quizzes to verify understanding.

4. Integrate by Organ System

Once basic knowledge is established, move toward system-based study.

5. Use the QBank

Practice exam-style clinical questions.

6. Review Every Explanation

Analyze both correct and incorrect responses.

7. Take Discipline Assessments

Use the nine assessments to check progress.

8. Focus on High-Yield Material

Use targeted review as the exam approaches.

9. Move Toward Mixed Practice

Combine organ systems and disciplines to better reflect actual Step 1 reasoning.

Who Is This Course For?

The Kaplan USMLE Step 1 2026 course is designed for:

• Medical students preparing for USMLE Step 1
• International Medical Graduates
• U.S. medical students
• Students beginning Step 1 content review
• Students preparing during preclinical medical school
• Students entering dedicated Step 1 study
• Learners with foundational science weaknesses
• Students seeking a structured video curriculum
• Students who prefer discipline-based learning
• Students who prefer organ-system integration
• Students who want both video learning and question-based practice

Key Features

• Nearly 1,200 instructional videos
• 1,600+ additional module questions
• 3,000+ Step 1 QBank questions
• Diagnostic examination
• 9 discipline assessment exams
• Kaplan USMLE Step 1 Lecture Notes
• Discipline-based learning
• Organ-system-based learning
• High-yield content filtering
• Integrated foundational science review
• Clinical correlations
• Question-based reinforcement

Why This Course Is Relevant

USMLE Step 1 increasingly emphasizes integrated foundational science rather than isolated memorization.

Students must connect mechanisms across:

• Pathology
• Physiology
• Pharmacology
• Microbiology
• Anatomy
• Biochemistry
• Immunology
• Behavioral science

The Kaplan USMLE Step 1 2026 program supports this style of learning by allowing students to begin with individual disciplines and then reorganize their study around organ systems.

The combination of nearly 1,200 videos, 1,600+ quiz questions, 3,000+ QBank questions, Lecture Notes, diagnostic testing, and discipline assessments creates a comprehensive framework for long-term Step 1 preparation.

Important Product Information

This MedicalAmboss listing contains:

Videos + Quizzes + Questions with Answers

Kaplan’s official commercial courses may separately include additional services or online platform features such as:

• Personalized study calendars
• AI tutoring
• Advising sessions
• Full-length simulated examinations
• Performance dashboards
• Live instruction
• Private tutoring

Those additional features should not be assumed to be included with this MedicalAmboss product unless specifically listed with the files or access provided.

Official Program Summary

This summary describes the source program, not verified file counts or subscription entitlements for the retailer’s package.

Kaplan USMLE Step 1 2026 (Videos + Quiz + Questions with Answers) provides a comprehensive Step 1 review with nearly 1,200 instructional videos, 1,600+ module quiz questions, and a 3,000+ question Kaplan Step 1 QBank. Review Anatomy, Behavioral Sciences, Biochemistry, Immunology, Microbiology, Physiology, Pathology and Pharmacology by discipline or integrate learning across cardiovascular, respiratory, renal, GI, endocrine, reproductive, nervous and other major organ systems.