UCSF 15th International Conference Neonatal & Childhood Pulmonary Vascular Disease 2022

Comprehensive Updates in Pediatric, Neonatal, and Adult Pulmonary Vascular Disease

Overview

UCSF 15th International Conference on Neonatal & Childhood Pulmonary Vascular Disease 2022 is a specialized multidisciplinary educational program focused on the diagnosis, pathobiology, genetics, and treatment of pulmonary vascular diseases affecting neonates, children, and adults.

Organized by the Department of Pediatrics at University of California San Francisco, this international conference brings together leading experts in pediatric pulmonology, cardiology, critical care, neonatology, genetics, and pulmonary hypertension research to discuss emerging scientific discoveries and advances in patient management.

The symposium highlights the growing recognition that pulmonary vascular pathology plays a critical role in numerous neonatal and childhood disorders and explores how advances in developmental biology, genomics, and targeted therapies are transforming clinical care.

Course Specifications

Format

• 6 Video Lectures
• 38 PDF Presentations

Activity Dates

February 24–26, 2022

Department

Pediatrics

File Size

17.1 GB

Educational Level

Intermediate to Advanced

Specialty

Pediatric Pulmonary Hypertension & Pulmonary Vascular Disease

Provider

University of California San Francisco

Learning Objectives

Upon completion of this conference, participants should be able to:

• Apply new knowledge of developmental pulmonary vascular biology.
• Improve early recognition of pulmonary vascular disease in neonates and children.
• Assess current and emerging therapies for pulmonary hypertension.
• Understand genetic and genomic contributors to pulmonary vascular disorders.
• Implement multidisciplinary approaches to patient management.
• Evaluate global challenges in pulmonary vascular disease care.
• Review recent scientific breakthroughs affecting diagnosis and treatment.
• Support improved outcomes through collaborative care models.

Core Topics Covered

Developmental Pulmonary Vascular Biology

Topics Include

• Fetal Pulmonary Circulation
• Vascular Development
• Neonatal Pulmonary Adaptation
• Pulmonary Vascular Remodeling
• Endothelial Dysfunction

Participants gain insight into the biological mechanisms underlying pulmonary vascular disease.

Neonatal Pulmonary Vascular Disease

Topics Include

• Persistent Pulmonary Hypertension of the Newborn (PPHN)
• Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension
• Prematurity-Related Pulmonary Vascular Disease
• Early Detection Strategies

Special focus is placed on improving outcomes through earlier recognition and intervention.

Pediatric Pulmonary Hypertension

Topics Include

• Classification of Pediatric Pulmonary Hypertension
• Diagnostic Evaluation
• Hemodynamic Assessment
• Risk Stratification
• Long-Term Management

Congenital Heart Disease and Pulmonary Vascular Disease

Topics Include

• Eisenmenger Syndrome
• Pulmonary Hypertension Associated with Congenital Heart Disease
• Postoperative Pulmonary Vascular Disease
• Right Ventricular Adaptation

Genetics and Genomics

One of the major themes of the conference.

Topics Include

• Genetic Causes of Pulmonary Hypertension
• Heritable Pulmonary Arterial Hypertension
• Genomic Research Advances
• Precision Medicine Approaches
• Genetic Counseling

Participants review the rapidly expanding role of genetics in diagnosis and risk assessment.

Current Therapeutic Strategies

Topics Include

• Endothelin Receptor Antagonists
• Phosphodiesterase-5 Inhibitors
• Prostacyclin Therapies
• Combination Therapy
• Advanced Pulmonary Hypertension Treatments

Future and Emerging Therapies

Topics Include

• Novel Drug Development
• Targeted Molecular Therapies
• Regenerative Medicine
• Personalized Treatment Approaches

Critical Care and Multidisciplinary Management

Topics Include

• Intensive Care Management
• Cardiorespiratory Support
• Nursing Integration
• Multidisciplinary Team Approaches
• Transition of Care

Global Pulmonary Vascular Disease

Topics Include

• Challenges in Low- and Middle-Income Countries
• Access to Specialized Care
• Resource-Limited Management Strategies
• International Health Perspectives

Basic and Translational Science

Topics Include

• Vascular Remodeling Mechanisms
• Inflammation
• Cellular Signaling Pathways
• Experimental Therapeutics
• Translational Research

Career Development and Mentorship

Topics Include

• Academic Career Planning
• Research Opportunities
• Mentorship for Trainees
• Professional Development

A unique component aimed at fellows, junior faculty, and early-career clinicians.

Educational Features

International Expert Faculty

Features leaders in pediatric pulmonary hypertension, cardiology, neonatology, and vascular biology.

Translational Focus

Bridges basic science discoveries with clinical applications.

Multidisciplinary Perspective

Integrates pulmonology, cardiology, neonatology, critical care, nursing, and genetics.

Comprehensive Resource Library

Includes extensive PDF materials for ongoing reference and study.

Target Audience

Physicians

• Pediatric Pulmonologists
• Adult Pulmonologists
• Pediatric Cardiologists
• Adult Cardiologists
• Critical Care Physicians
• Neonatologists
• Pediatric Intensivists

Advanced Practice Providers

• Nurse Practitioners
• Physician Assistants

Nurses

• Neonatal Nurses
• Pediatric Cardiology Nurses
• Pulmonary Hypertension Specialists

Trainees

• Pediatric Fellows
• Cardiology Fellows
• Pulmonary Fellows
• Neonatology Fellows

Why This Course Stands Out

• Dedicated exclusively to neonatal and childhood pulmonary vascular disease.
• Strong focus on genetics and developmental vascular biology.
• Covers both pediatric and adult pulmonary hypertension.
• Combines cutting-edge research with practical clinical management.
• Includes mentorship and career development content for future specialists.

 Topics:

*Note: these are continuous video recordings during the conference, they include individual lectures mentioned in the Detail section below

• 001_MPD22002_Syllabus_Intro.pdf
• 01_BRUNEAU_Development_RV.pdf
• 01_FRI_PEYVANDI_Pulmonary_Vasculature .pdf
• 02_LEVY_Right Ventricular.pdf
• 02_REDINGTON_RV_Response.pdf
• 03_THURS_FREIDBERG_RV_Function.pdf
• 03_ZANI_Novel_Approaches.pdf
• 04_FRI_LAKSHMINRUSIMHA_Pre-term_Newborn.pdf
• 04_MOLEDINA_UCSF.pdf
• 05_Single_Cell.pdf
• 05_THURS_ROSS_Pulmonary_Embolism.pdf
• 06b_FRI_HUMBERT_Robyn Barst.pdf
• 06_KELLER_Ductal_Patency.pdf
• 07_AMIN_Transcatheter_Therapy.pdf
• 07_FAIRCLOTH_Pharmacotherapy.pdf
• 08_FRI_ARCHER_SARS-CoV-2_Mitochondriopathy .pdf
• 08_THURS_COLEMAN_RVF_Survey.pdf
• 10_THUR_CAPLAN_Failing_RV.pdf
• 11_a_THURS_COULSON_RV_Failure.pdf
• 11_b_Mechanical_and_Surgical_Support.pdf
• 11_ROSENZWEIG_COVID_in_Peds.pdf
• 11_THURS_EGHTESADY_Failing_RV.pdf
• 12_LEONARD_Wellbeing.pdf
• 13_WHETSTONE_Contraception_AUB.pdf
• 14_KELLY_Adolescent_Mental_Health.pdf
• 19_Registry_Update.pdf
• 2022-02-16_MPD22002_Feb_25-26_General_Session.pdf
• 20_KRISHNAN_PVS_Medical_Therapy.pdf
• 21_HIRSCH_2022 Update.pdf
• 22_SAT_CALDERONE_Surgical_Update.pdf
• 23_Review_Basic_Science_Literature.pdf
• 24_Ivy_UCSF.DDI.pdf
• 25_BHernan_PH_Presentation.pdf
• 25_b_Cruz-Utrilla_SFO2.pdf
• 25_c_Ivy. Actigraphy.pdf
• 26_ROSENZWEIG_PVDOMICS.pdf
• 28_SAT_EVERETT_Pediatric_Survial.pdf
• 31_a_GRIFFITHS_PHUZZLERS.pdf
• February 24 AM Session.mp4 (3 hours 40 minutes)
• February 24 PM Session.mp4 (3 hours)
• February 25 AM Session.mp4 (4 hours)
• February 25 PM Session.mp4 (6 hours)
• February 26 AM Session.mp4 (3 hours)
• February 26 PM Session.mp4 (4 hours)

*Detail:

Thursday, February 24, 2022

7:30am PT Registration and Coffee
7:50 Welcome and Introduction Drs. Ryan Coleman and Lew Romer

• SESSION 1: DEVELOPMENT AND ASSESSMENT OF THE RIGHT VENTRICLE Moderators: Drs. Maria Del Cerro and Hythem Nawaytou
  8:00 1. Development of the Right Ventricle Dr. Benoit Bruneau
  8:30 2. The RV Response to Acute and Chronic Increases in Afterload Dr. Andrew Redington
  9:00 3. Assessment of RV Function: The Role of Echocardiography Dr. Mark Friedberg
  9:30 4. Assessment of RV Function: The Role of MRI/CT Dr. Shahin Moledina
  10:00 5. Acute Pulmonary Embolism: Diagnosis and Treatment (Recorded) Dr. Catherine Ross
  10:30 Moderated Q&A
  11:00 Break
• SESSION 2: MANAGEMENT OF THE FAILING RIGHT VENTRICLE – PART I Moderators: Drs. Corey Chartan and Vamsi Yarlagadda
  11:15 6. Maintaining Ductal Patency in Neonatal RV Dysfunction Dr. Roberta Keller
  11:45 7. Catheter-Based Interventions for the Failing RV Dr. Elena Amin
  12:15 Moderated Q & A
  1:00 pm PT Lunch on Your Own
• SESSION 3: MANAGEMENT OF THE FAILING RIGHT VENTRICLE – PART II Moderators: Drs. Ryan Coleman and Satish Rajagopal
  2:30 8. ICU Management: A Spectrum of Approaches (Report of an InternationalSurvey) Dr. Ryan Coleman
  2:45 9. Approaching the Failing RV: The Cardiac Intensivist’s Perspective Dr. Mjaye Mazwi
  3:15 10. Approaching the Failing RV: The Anesthesiologist’s Perspective Dr. Lisa Caplan
  3:45 11. Mechanical and Surgical Support for the Failing RV Drs. Pirooz Eghtesady and Mark Grady
  4:45 Moderated Q&A
  5:15 Challenging Cases
  5:45 pm PT Closing Remarks and Adjourn

FRIDAY, FEBRUARY 25th, 2022

• 7:00 am Registration and Continental Breakfast
  7:45 Welcome and Opening Remarks
• SESSION 1: NEW MECHANISMS AND POTENTIAL THERAPIES FOR NEONATAL PULMONARY DISEASE MODERATORS: Drs. Roberta Keller and Bernard Thébaud
  8:00 1. Fetal Evaluation of the Pulmonary Vasculature in at Risk Populations Dr. Shabnam Peyvandi
  8:25 2. Right Ventricular–Pulmonary Vascular Interactions in the Neonate and Infant: Role of Standard and Novel Imaging Techniques to Detect Detrimental Changes Dr. Phil Levy
  8:50 3. Novel Approaches to Developmental Lung Diseases of the Pulmonary Vasculature: Antenatal Cell-Based Interventions for CDH Dr. Augusto Zani
  9:15 4. What’s Old is Still Relevant: The Role of Inhaled Nitric Oxide in the Pre-term Newborn Dr. Satyan Lakshminrusimha
  9:40 Break
• SESSION 2: Special Scientific Presentations MODERATORS: Drs. Steven Abman and Lew Romer
  9:55 5. Special Lecture: Leveraging Multi-Omics in Vascular Biology Dr. Cristina Alvira
  10:20 6. The Lucas Van Wormer Best Trainee Research Award Introduction: Dr. Dunbar Ivy Clinical Phenotype and Treatment Strategies in Children with Pulmonary Hypertension And TBX4 Disease Dr. Cara Morgan
  10:55 Introduction: The Robyn Barst Keynote Lecture Dr. Bernard Thébaud
  11:00 KEYNOTE SPEAKER: The Robyn Barst Keynote Lecture (Recorded) Genotype Phenotype Relationships in Heritable Pulmonary Hypertension Dr. Marc Humbert
  12:00-1:15 pm Lunch on Own
• SESSION 3: Pediatric Drug Delivery: A Practical Discussion
  1:15 pm – 2:00 pm MODERATORS: Elizabeth Colglazier and Emma Jackson
  1:15 7. Jenna Faircloth, PharmD, BCPS
• SESSION 4: COVID 19 and the Pulmonary Vasculature: Lessons Learned MODERATORS: Drs. Jason Boehme and Eric Austin
  2:00 8. A SARS-CoV-2 Mitochondriopathy in COVID-19 Pneumonia Dr. Stephen Archer
  2:25 9. COVID: Animal Models and Clinical Trials (Recorded) Dr. Duncan Stewart
  2:50 10. COVID Pulmonary Vasculature Pathology (Recorded) Dr. Csaba Galambos
  3:15 11. COVID in Childhood and PH Patients Dr. Erika Rosenzweig
  3:40 Break
• SESSION 5: Caring for the Adolescent Patient with Pulmonary Hypertension MODERATORS: Claire Parker and Michelle Ogawa
  3:50 12. Using a Strengths-Based Approach to Promote Adolescent Wellbeing Adam Leonard, PNP, MPH
  4:20 13. Management of Abnormal Uterine Bleeding and Contraception Dr. Sara Whetstone
  4:50 14. PH: Mental Health Dr. Sarah Kelly
  5:20 15. Palliative Care and Advanced Directives (Recorded) Dr. Alison Miles
  5:45 16. Pathology Round Table Dr. Csaba Galambos
  6:45 pm Adjourn

SATURDAY, FEBRUARY 26th, 2022

• 6:30 am Continental Breakfast
  7:00 18. Sunrise Discussion: Meet the Mentors: Small Groups Sessions Round Table Topics Include: Clinical PH Training and Starting and Maintaining a Multi-Disciplinary PH Program
• SESSION 5: Pulmonary Vein Stenosis: An Update MODERATORS: Drs. Rachel Vanderlaan and Emily Morell
  8:00 19. PVS Network: General Update Dr. Rachel Vanderlaan
  8:15 20. Medical Therapies: An Update Dr. Usha Krishnan
  8:40 21. Catheter-Based Therapy: An Update Dr. Russel Hirsch
  9:05 22. Surgical Therapies: An Update (Recorded) Dr. Chris Caldarone
  9:30 am Break
• SESSION 6: SCIENTIFIC SESSION INCLUDING ABSTRACT POSTER SYMPOSIUM (10:00 am – 12:30 pm – General Session Room) MODERATORS: Drs. Sanjeev Datar and Bernard Thébaud
  11:00 23. The Year in Review: Basic Science Dr. Usha Raj
  11:30 24. The Year in Review: Clinical Science Dr. Dunbar Ivy
  12:00 pm 25. Platform Sessions: Brief Poster Oral Discussions
  12:30 Boxed Lunch

SESSION 7: PANEL DISCUSSION: The Genotype-Phenotype Approach to the PAH Patient Faculty: Drs. Eric Austin, Wendy Chung, and Erika Rosenzweig
1:15 PVDOMICS Dr. Erika Rosenzweig

SESSION 8: Risk Assessment and Therapeutic Updates MODERATORS: Drs. Maria Del Cerro and Rachel Hopper
2:15 27. Risk Assessment of Pulmonary Arterial Hypertension Dr. Raymond Benza
2:45 28. Risk Assessment: Pediatric Perspectives (Recorded) Dr. Allen Everett
3:15 29. Therapeutic Approach to the Newly Diagnosed Patient: Mono, Duel, or Triple? Dr. Rolf Berger
3:45 30. New and Future Therapies for PAH and RV failure Dr. Paul Yu
4:00 Break
4:15 31. Case Presentations: The PHuzzlers
5:30 pm Closing Remarks and Adjour