Cleveland Clinic Advanced Endoscopy Course 2025 (CADEC)

Advanced Endoscopy, Metabolic Endoscopy & Third-Space Endoscopy Masterclass

Overview

The Cleveland Clinic Advanced Endoscopy Course (CADEC) 2025 is the fourth annual edition of Cleveland Clinic’s premier international symposium dedicated to advanced therapeutic endoscopy, bariatric endoscopy, interventional EUS, and third-space endoscopic procedures. Designed for experienced endoscopists and gastrointestinal specialists, this intensive program bridges the gap between medical gastroenterology and surgical intervention through innovative, minimally invasive, and organ-preserving techniques.

The 2025 course places special emphasis on the rapidly evolving fields of Metabolic Endoscopy and Third-Space Endoscopy, highlighting how advanced endoscopic procedures can be integrated with modern pharmacologic therapies such as GLP-1 receptor agonists to optimize patient outcomes. Participants gain practical insights into endoscopic sleeve gastroplasty (ESG), transoral outlet reduction (TORe), peroral endoscopic myotomy (POEM), endoscopic submucosal dissection (ESD), interventional endoscopic ultrasound (EUS), and complex defect closure techniques.

A unique feature of CADEC is its extensive hands-on simulation laboratory, where attendees practice advanced procedures using ex-vivo models under the guidance of internationally recognized faculty. This immersive learning environment allows clinicians to translate theory into technical expertise and improve procedural confidence.

Course Specifications

Format

• 7 Video Lectures (.MP4)
• 7 Audio Recordings (.MP3)
• 7 Subtitle Files (.VTT)
• 1 PDF Course Material

Course Size

3.36 GB

Course Dates

September 26–27, 2025

Location

InterContinental Cleveland Hotel & Cleveland Clinic Simulation Skills Center

Cleveland, Ohio, USA

Course Director

Roberto Simons-Linares, MD

Learning Objectives

After completing this course, participants should be able to:

• Integrate pharmacologic weight-loss therapies with bariatric endoscopic procedures.
• Perform patient selection for endoscopic sleeve gastroplasty (ESG) and transoral outlet reduction (TORe).
• Understand technical approaches to esophageal and gastric endoscopic submucosal dissection (ESD).
• Apply advanced traction and dissection techniques to improve procedural safety and efficiency.
• Manage endoscopic complications including perforations, leaks, and fistulas.
• Utilize endoscopic vacuum therapy (EVT) and advanced closure methods.
• Perform interventional EUS procedures using lumen-apposing metal stents (LAMS).
• Evaluate indications for POEM, Z-POEM, and other third-space endoscopic procedures.
• Understand emerging applications of robotic-assisted endoscopy and future endoscopic technologies.

Course Topics

1. Endoscopic Closure Methods for Esophageal Perforation

Management of esophageal perforations remains one of the most challenging situations in therapeutic endoscopy.

Topics Include

• Over-the-Scope Clips (OTSC)
• Endoscopic Suturing
• Endoscopic Vacuum Therapy (EVT)
• Stent Placement Strategies
• Leak Prevention and Management

Participants learn practical techniques for managing both acute and delayed perforations.

2. Engineering Access: Addressing Biliary Obstruction in Complex Surgical Reconstruction

Advanced approaches to biliary access in patients with altered anatomy.

Covered Topics

• Roux-en-Y Anatomy
• Post-Surgical Biliary Obstruction
• EUS-Guided Access
• ERCP Alternatives
• Advanced Biliary Drainage Techniques

3. Obesity and GERD – What Are the Options?

A comprehensive review of minimally invasive treatment strategies for obesity and reflux disease.

Topics Include

• Endoscopic Sleeve Gastroplasty (ESG)
• Transoral Outlet Reduction (TORe)
• Medical Weight-Loss Therapies
• GLP-1 Receptor Agonists
• Gastroesophageal Reflux Disease Management
• Endoscopic Anti-Reflux Procedures

4. Updates in Barrett’s Esophagus

Current advances in the diagnosis, surveillance, and treatment of Barrett’s esophagus.

Topics Include

• Risk Stratification
• Endoscopic Eradication Therapy
• Radiofrequency Ablation (RFA)
• Cryotherapy
• Dysplasia Management
• Surveillance Guidelines

5. Endoscopic Management of a Complex Rectal Perforation

Real-world strategies for managing advanced colorectal complications.

Covered Topics

• Endoscopic Closure Techniques
• Defect Assessment
• Clip-Based Therapy
• Endoscopic Suturing
• Avoiding Surgical Intervention

6. What’s New in Interventional EUS?

A review of the latest innovations in therapeutic endoscopic ultrasound.

Topics Include

• Lumen-Apposing Metal Stents (LAMS)
• Gallbladder Drainage
• Pancreatic Fluid Collection Drainage
• EUS-Guided Anastomosis
• Advanced EUS Techniques

Participants learn how EUS is transforming minimally invasive gastrointestinal interventions.

7. Third-Space Endoscopy Update – POEM

One of the fastest-growing fields in advanced endoscopy.

Topics Include

• Peroral Endoscopic Myotomy (POEM)
• Z-POEM for Zenker’s Diverticulum
• Gastric POEM (G-POEM)
• Endoscopic Submucosal Tunneling
• Achalasia Management
• Third-Space Endoscopy Innovations

Major Educational Themes

Metabolic Endoscopy

A major focus of CADEC 2025 is integrating endoscopic therapies with modern obesity medications.

Topics Include

• GLP-1 Agonists
• ESG and TORe
• Multidisciplinary Weight Management
• Obesity Treatment Algorithms
• Long-Term Outcome Optimization

Endoscopic Submucosal Dissection (ESD)

Detailed instruction on:

• Esophageal ESD
• Gastric ESD
• Eastern vs. Western Techniques
• Traction Methods
• En Bloc Resection Strategies
• Complication Prevention

Complication Management

Practical approaches to difficult situations.

Topics Include

• Perforation Management
• Anastomotic Leaks
• Fistula Closure
• Advanced Suturing
• Vacuum-Assisted Therapy

Emerging Technologies

The course explores future innovations in therapeutic endoscopy.

Topics Include

• Endorobotics
• AI-Assisted Endoscopy
• Advanced Imaging
• Robotic Endoscopic Platforms
• Next-Generation Therapeutic Devices

Hands-On Skills Laboratory

One of the most valuable components of CADEC is its extensive simulation training.

Practical Training Includes

• POEM
• Z-POEM
• ESG
• TORe
• Endoscopic Suturing
• TIF (Transoral Incisionless Fundoplication)
• ESD Techniques
• Defect Closure

Participants receive direct instruction from expert faculty while performing procedures on realistic ex-vivo models.

Target Audience

Physicians

• Advanced Endoscopists
• Gastroenterologists
• Bariatric Surgeons
• Therapeutic Endoscopists
• Foregut Surgeons
• Interventional Gastroenterologists

Allied Healthcare Professionals

• Endoscopy Nurses
• GI Technologists
• Endoscopy Unit Managers
• Surgical Assistants

Trainees

• Gastroenterology Fellows
• Advanced Endoscopy Fellows
• Surgical Trainees

Why This Course Stands Out

Extensive Hands-On Training

Features large-scale simulation laboratories rarely available at other endoscopy meetings.

Focus on Modern Endoscopic Therapies

Covers cutting-edge procedures including POEM, ESG, TORe, ESD, and advanced EUS interventions.

Multidisciplinary Faculty

Combines expertise from gastroenterology, bariatric surgery, and advanced therapeutic endoscopy.

Immediate Clinical Relevance

Provides practical techniques that can be implemented directly into advanced endoscopy practice.

Future-Oriented Education

Includes emerging technologies such as endorobotics and next-generation endoscopic interventions.