Harvard Update on Severe Asthma 2026

Advanced Severe Asthma, Biologic Therapy & Precision Pulmonary Medicine Update

The Harvard Update on Severe Asthma 2026, presented by Brigham and Women’s Hospital and Harvard Medical School, is a comprehensive continuing medical education program dedicated to the diagnosis, evaluation, and management of difficult-to-control and severe asthma in both adult and pediatric populations.

Designed for pulmonologists, allergists, internists, pediatric specialists, and healthcare professionals involved in asthma care, this intensive course provides the latest evidence-based strategies for understanding asthma phenotypes, immunologic mechanisms, genetic influences, and emerging targeted therapies. Participants gain practical knowledge on applying modern treatment algorithms, selecting appropriate biologic therapies, and implementing precision medicine approaches for patients with complex asthma.

The course incorporates updated recommendations from the latest GINA (Global Initiative for Asthma) and NAEPP (National Asthma Education and Prevention Program) guidelines, helping clinicians optimize outcomes for patients with severe and treatment-resistant asthma.

Product Details

• Course: Harvard Update on Severe Asthma 2026
• Provider: Brigham and Women’s Hospital / Harvard Medical School
• Release Date: March 16, 2026
• Format: Videos + PDFs
• Access: On-Demand

Program Overview

Severe asthma remains a major clinical challenge despite significant advances in biologic therapies and personalized medicine. Many patients continue to experience uncontrolled symptoms, recurrent exacerbations, reduced quality of life, and increased healthcare utilization.

This course provides an in-depth review of:

• Severe Asthma Phenotypes
• Asthma Endotypes
• Immunologic Mechanisms
• Precision Medicine
• Biologic Therapies
• Pediatric Severe Asthma
• Occupational Asthma
• Obesity-Associated Asthma
• Aspirin-Exacerbated Respiratory Disease (AERD)
• Eosinophilic Lung Disorders
• Psychiatric Comorbidities
• Population Health Strategies

Through expert-led lectures, clinical case discussions, and practical management strategies, participants gain a comprehensive understanding of contemporary severe asthma care.

Learning Objectives

Upon completion of this activity, participants will be able to:

• Identify severe asthma phenotypes and endotypes using modern diagnostic approaches.
• Apply updated GINA and NAEPP recommendations in clinical practice.
• Select appropriate biologic therapies based on individual patient characteristics.
• Recognize immunologic and genetic factors contributing to severe asthma.
• Diagnose and manage eosinophilic and other inflammatory airway disorders.
• Develop treatment plans for obesity-related and occupational asthma.
• Evaluate patients with aspirin-exacerbated respiratory disease (AERD).
• Address psychiatric and behavioral comorbidities affecting asthma control.
• Integrate precision medicine approaches into severe asthma management.
• Improve outcomes through multidisciplinary and population-based care strategies.

Core Topics Covered

Severe Asthma Phenotypes & Endotypes

• Type 2 Inflammation
• Eosinophilic Asthma
• Non-Eosinophilic Asthma
• Biomarker-Based Assessment
• Precision Phenotyping

Asthma Immunology & Genetics

• Airway Inflammation
• Cytokine Pathways
• IgE-Mediated Disease
• Genetic Susceptibility
• Emerging Molecular Targets

Biologic Therapies

• Anti-IgE Therapy
• Anti-IL-5 Agents
• Anti-IL-5 Receptor Therapies
• Anti-IL-4/IL-13 Therapies
• Biologic Selection Strategies
• Monitoring Treatment Response

Precision Medicine in Asthma

• Personalized Treatment Approaches
• Biomarker-Guided Therapy
• Individualized Risk Assessment
• Future Therapeutic Targets

Aspirin-Exacerbated Respiratory Disease (AERD)

• Clinical Recognition
• Diagnostic Evaluation
• Medical Management
• Biologic Options
• Aspirin Desensitization Strategies

Eosinophilic Lung Disorders

• Differential Diagnosis
• Laboratory Evaluation
• Imaging Considerations
• Treatment Strategies

Obesity-Related Asthma

• Pathophysiology
• Metabolic Influences
• Weight-Loss Interventions
• Comprehensive Management

Occupational Asthma

• Workplace Exposures
• Diagnostic Testing
• Exposure Prevention
• Long-Term Management

Pediatric Severe Asthma

• Childhood Asthma Phenotypes
• Biologic Therapy in Children
• Growth and Development Considerations
• Long-Term Outcomes

Psychiatric Comorbidities

• Anxiety and Asthma
• Depression and Symptom Burden
• Behavioral Health Integration
• Patient Adherence

Population Health & Asthma Care

• Health Equity
• Quality Improvement Initiatives
• Reducing Exacerbations
• Healthcare Utilization Reduction

Educational Features

✔ Harvard Medical School Faculty

✔ Brigham and Women’s Hospital Experts

✔ Evidence-Based Clinical Guidelines

✔ Precision Medicine Approaches

✔ Advanced Biologic Therapy Reviews

✔ Adult and Pediatric Asthma Management

✔ Interactive Clinical Case Discussions

✔ Practical Real-World Applications

Who Should Use This Course?

• Pulmonologists
• Allergists and Immunologists
• Internal Medicine Physicians
• Family Medicine Physicians
• Pediatric Pulmonologists
• Pediatric Allergists
• Nurse Practitioners
• Physician Assistants
• Respiratory Therapists
• Asthma Care Specialists

Why This Course Matters

The management of severe asthma has evolved rapidly with the introduction of biologic therapies, precision medicine strategies, and improved understanding of asthma endotypes. Clinicians must stay current with emerging evidence, guideline updates, and individualized treatment approaches to improve disease control and reduce exacerbations.

This course provides practical, evidence-based guidance that helps healthcare professionals deliver modern, personalized care for patients with severe and difficult-to-control asthma.

Clinical & Educational Value

The Harvard Update on Severe Asthma 2026 offers a comprehensive review of modern severe asthma management, integrating advances in immunology, genetics, biologic therapies, precision medicine, and multidisciplinary care.

By combining cutting-edge scientific knowledge with practical clinical guidance, this program equips clinicians with the tools necessary to improve outcomes for patients with complex asthma and related airway disorders.