Kaplan USMLE Step 1 2026 (Videos + Quiz + Questions with Answers)

Kaplan USMLE Step 1

This Kaplan USMLE Step 1 package brings together videos, quizzes and questions with answers for reviewing the basic sciences. Study can be organized by discipline—such as anatomy, physiology, pathology and pharmacology—or around organ systems to connect mechanisms with clinical presentations. It is intended for medical students and graduates building their foundation for USMLE Step 1.

The topic lists below describe the source curriculum and retain the subjects from this listing. They are not a verified lesson-by-lesson file inventory. Kaplan’s advertised video and question totals, lecture-note access, diagnostic assessments and platform features should not be assumed to be included in this package; consult the sample for the supplied materials. Official Kaplan account access, tutoring and study dashboards are separate.

Discipline-Based Review

Anatomy

• Gross anatomy
• Neuroanatomy
• Musculoskeletal anatomy
• Embryology
• Anatomical relationships
• Clinical correlations

Behavioral Sciences

• Biostatistics
• Epidemiology
• Ethics
• Patient communication
• Behavioral medicine
• Health systems
• Population health
• Clinical decision-making

Biochemistry

• Metabolic pathways
• Molecular biology
• Genetics
• Enzyme function
• Cellular metabolism
• DNA and RNA
• Gene expression
• Nutritional biochemistry

Immunology

• Innate immunity
• Adaptive immunity
• Antibodies
• T-cell function
• B-cell function
• Hypersensitivity
• Autoimmunity
• Immunodeficiency
• Vaccination

Microbiology

• Bacteria
• Viruses
• Fungi
• Parasites
• Antimicrobial mechanisms
• Host-pathogen interaction

Physiology

• Cardiovascular physiology
• Pulmonary physiology
• Renal physiology
• Gastrointestinal physiology
• Endocrine physiology
• Reproductive physiology
• Neurophysiology
• Acid-base physiology

Pathology

• Mechanisms of disease
• Cellular injury
• Inflammation
• Neoplasia
• Organ-system pathology
• Histopathology
• Clinical disease patterns

Pharmacology

• Pharmacokinetics
• Pharmacodynamics
• Mechanisms of action
• Drug interactions
• Adverse effects
• Therapeutic indications
• Toxicology
• System-specific pharmacology

Organ-System-Based Review

Foundations of Medicine

• Cellular biology
• Genetics
• Immunology
• Pathology
• Pharmacologic principles
• Molecular mechanisms

Nervous System

• Neuroanatomy
• Neurophysiology
• Neuropathology
• Neurology
• Neuropharmacology

Cardiovascular System

• Hemodynamics
• Cardiac physiology
• Murmurs
• Ischemic heart disease
• Heart failure
• Arrhythmias
• Hypertension
• Cardiovascular pharmacology

Respiratory System

• Pulmonary physiology
• Ventilation and perfusion
• Acid-base physiology
• Obstructive disease
• Restrictive disease
• Pulmonary pathology
• Respiratory pharmacology

Renal System

• Renal physiology
• Glomerular function
• Tubular transport
• Electrolytes
• Acid-base disorders
• Kidney disease
• Renal pharmacology

Gastrointestinal System

• Anatomy
• Physiology
• Digestion
• Absorption
• Pathology
• Liver disease
• Pancreatic disease
• GI pharmacology

Endocrine System

• Hormonal physiology
• Feedback mechanisms
• Pituitary disease
• Thyroid disorders
• Adrenal disease
• Diabetes
• Calcium metabolism
• Endocrine pharmacology

Reproductive System

• Male reproductive anatomy
• Female reproductive anatomy
• Reproductive physiology
• Embryology
• Pregnancy
• Reproductive pathology
• Hormonal pharmacology

Musculoskeletal, Skin & Connective Tissue

• Musculoskeletal anatomy
• Bone physiology
• Muscle disease
• Dermatology
• Rheumatology
• Connective tissue disorders
• Autoimmune disease

Hematology & Oncology

• Anemia
• Hemoglobin disorders
• Coagulation
• Leukemia
• Lymphoma
• Cancer biology
• Oncogenes
• Tumor suppressors
• Chemotherapy principles

Immune System

• Immunodeficiency
• Hypersensitivity
• Autoimmune disease
• Transplant immunology
• Immune therapies
• Vaccine mechanisms

Infectious Disease

• Pathogen identification
• Disease patterns
• Antimicrobial mechanisms
• Resistance
• Appropriate therapy
• Host response