NYU Langone Health Cardiac Amyloidosis: Diagnosis and Novel Therapeutics in 2024

Comprehensive Update on Cardiac Amyloidosis, Advanced Imaging, Heart Failure, Electrophysiology, and Emerging Therapies

Overview

NYU Langone Health Cardiac Amyloidosis: Diagnosis and Novel Therapeutics in 2024 is a specialized multidisciplinary educational program dedicated to the diagnosis, imaging, treatment, and long-term management of patients with amyloidosis, with a particular focus on cardiac involvement.

Presented by the expert amyloidosis team at NYU Langone Health, this course provides a comprehensive review of modern approaches to cardiac amyloidosis, including advances in multimodality imaging, electrophysiology, advanced heart failure therapies, transplantation, novel pharmacologic treatments, and ongoing clinical trials.

The program emphasizes collaboration among cardiologists, hematologists, neurologists, gastroenterologists, nephrologists, and other specialists involved in caring for patients with systemic amyloidosis.

This educational activity includes 1 comprehensive video presentation and 17 PDF resources covering the latest developments in amyloidosis diagnosis and management.

Course Specifications

Format

• 1 Video Lecture
• 17 PDF Presentations

Course Year

2024

Date

September 19, 2024

Location

NYU Langone Health

Educational Level

Intermediate to Advanced

Specialty

Cardiac Amyloidosis & Advanced Heart Failure

Learning Objectives

Upon completion of this activity, participants should be able to:

• Diagnose various forms of amyloidosis accurately.
• Differentiate AL and ATTR amyloidosis.
• Utilize advanced imaging techniques for diagnosis and monitoring.
• Implement emerging therapies for cardiac amyloidosis.
• Recognize conduction system disease and arrhythmias associated with amyloidosis.
• Identify patients who may benefit from heart transplantation.
• Understand multidisciplinary approaches to patient management.
• Evaluate candidates for clinical trials and novel therapeutics.
• Develop specialized amyloidosis programs and clinics.

Core Topics Covered

Cardiac Amyloidosis Fundamentals

Topics Include

• Pathophysiology of Amyloidosis
• Cardiac Infiltrative Disease
• Disease Progression
• Clinical Presentation
• Early Recognition Strategies

Participants gain a strong foundation in recognizing and diagnosing cardiac amyloidosis.

Types of Amyloidosis

AL Amyloidosis

Topics Include:

• Plasma Cell Disorders
• Light Chain Amyloidosis
• Diagnostic Workup
• Hematologic Treatment Strategies
• Clinical Outcomes

ATTR Amyloidosis

Topics Include:

• Wild-Type ATTR
• Hereditary ATTR
• Genetic Testing
• Disease Progression
• Modern Therapeutic Approaches

Comprehensive review of differentiating amyloid subtypes and selecting appropriate treatment pathways.

Advanced Cardiac Imaging

A major focus of the conference.

Topics Include

• Echocardiography
• Strain Imaging
• Cardiac Magnetic Resonance (CMR)
• Nuclear Imaging
• Bone Scintigraphy
• Multimodality Imaging Strategies

Participants learn the advantages and limitations of various imaging modalities used in diagnosis and follow-up.

Echocardiography in Amyloidosis

Topics Include

• Characteristic Echocardiographic Findings
• Global Longitudinal Strain
• Apical Sparing Pattern
• Diastolic Dysfunction
• Disease Monitoring

Cardiac MRI

Topics Include

• Tissue Characterization
• Late Gadolinium Enhancement
• Extracellular Volume Mapping
• Disease Severity Assessment
• Prognostic Value

Nuclear Cardiology Applications

Topics Include

• Technetium Scintigraphy
• ATTR Detection
• Diagnostic Algorithms
• Noninvasive Diagnosis

Advanced Heart Failure Management

Topics Include

• Heart Failure in Amyloidosis
• Medical Therapy
• Volume Management
• Disease Progression Monitoring
• Referral Strategies

Participants learn practical approaches to managing complex heart failure patients.

Heart Transplantation

Topics Include

• Patient Selection
• Transplant Evaluation
• Outcomes in Amyloidosis
• Advanced Therapies

Special attention is given to identifying appropriate transplant candidates.

Electrophysiology and Arrhythmias

Topics Include

• Conduction System Disease
• Atrial Fibrillation
• Ventricular Arrhythmias
• Bradyarrhythmias
• Sudden Cardiac Death Risk

Novel Pacing Strategies

Topics Include

• Physiologic Pacing
• Conduction System Pacing
• Device Therapy
• Cardiac Resynchronization

Participants review emerging approaches to rhythm management in amyloidosis patients.

Novel Therapeutics

Topics Include

• Transthyretin Stabilizers
• Gene-Silencing Therapies
• RNA-Based Treatments
• Emerging Pharmacologic Agents
• Future Therapeutic Directions

Review of groundbreaking advances transforming amyloidosis care.

AL Amyloidosis Updates

Topics Include

• Plasma Cell Directed Therapy
• Novel Chemotherapy Approaches
• Immunotherapy
• Clinical Trial Updates
• Multiple Myeloma Overlap

Expert faculty provide updates from the latest research and clinical trials.

Clinical Trials and Research

Topics Include

• Ongoing Therapeutic Trials
• Patient Recruitment Strategies
• Advanced Disease Management
• Emerging Investigational Therapies

Participants learn how to identify patients who may benefit from enrollment in clinical trials.

Multisystem Manifestations of Amyloidosis

Neurologic Involvement

• Peripheral Neuropathy
• Autonomic Dysfunction

Gastrointestinal Manifestations

• GI Dysmotility
• Nutritional Challenges

Renal Disease

• Proteinuria
• Chronic Kidney Disease

Musculoskeletal Manifestations

• Orthopedic Features
• Carpal Tunnel Syndrome
• Functional Limitations

Comprehensive review of systemic amyloidosis beyond cardiac involvement.

Building an Amyloidosis Program

Topics Include

• Multidisciplinary Clinic Development
• Referral Networks
• Diagnostic Pathways
• Program Infrastructure
• Patient Access to Care

Educational Features

Multidisciplinary Faculty

Features experts from cardiology, hematology, electrophysiology, advanced heart failure, transplantation, neurology, nephrology, and gastroenterology.

Practical Clinical Focus

Emphasis on real-world diagnosis and management challenges.

Advanced Imaging Education

Comprehensive review of modern imaging techniques used in cardiac amyloidosis.

Emerging Therapies

Detailed coverage of rapidly evolving treatment options and clinical trials.

Target Audience

Physicians

• Cardiologists
• Heart Failure Specialists
• Internists
• Hematologists
• Oncologists
• Electrophysiologists
• Neurologists
• Nephrologists
• Gastroenterologists

Trainees

• Cardiology Fellows
• Internal Medicine Residents
• Hematology Fellows
• Heart Failure Fellows

Advanced Practice Providers

• Nurse Practitioners
• Physician Assistants
• Specialized Amyloidosis Care Teams

Why Choose This Course?

• Comprehensive focus on cardiac amyloidosis.
• Covers both diagnosis and emerging therapies.
• Strong emphasis on multimodality imaging.
• Includes advanced heart failure and transplant considerations.
• Reviews electrophysiology and pacing strategies.
• Features updates on ongoing clinical trials and novel therapeutics.
• Ideal for clinicians managing complex amyloidosis patients.

Topics:

• Agenda.pdf
  Advances in Positron Emission Tomography (PET) and Amyloidosis.pdf
  AL (Light Chain) Amyloidosis Non-Transplant Treatment.pdf
  AL (Light Chain) Amyloidosis Pathogenesis and Diagnosis.pdf
  Cardiac Electrophysiology and Amyloidosis.pdf
  Cardiac Imaging Echocardiography.pdf
  Cardiac Imaging Nuclear Imaging Modalities.pdf
  Creating and Developing an Amyloidosis Clinic.pdf
  Gastrointestinal Manifestations of Amyloidosis.pdf
  Neurological Manifestations of Amyloidosis.pdf
  New and Ongoing Clinical Trials in Amyloidosis NYULH Experience 1.pdf
  New and Ongoing Clinical Trials in Amyloidosis NYULH Experience 2.pdf
  Orthopedic and Musculoskeletal Manifestations of Amyloidosis.pdf
  Renal Manifestations of Amyloidosis.pdf
  Role of Cardiac Magnetic Resonance Imaging (MRI) in Amyloidosis.pdf
  The Future of Amyloidosis Treatment Gene Editing and Antibody Therapy.pdf
  Transthyretin Amyloidosis Emphasis on Cardiomyopathy.pdf
  September 19.mp4 (8 hours 48 minutes)