USCAP Practical Neoplastic and Non-Neoplastic Bone Pathology for the Surgical Pathologist 2026 (Videos + PDFs)

Comprehensive Bone Pathology Training for Modern Diagnostic Practice

The USCAP Practical Neoplastic and Non-Neoplastic Bone Pathology for the Surgical Pathologist 2026 is an advanced educational program developed by the United States and Canadian Academy of Pathology to provide practical, case-based training in the diagnosis of both neoplastic and non-neoplastic bone disorders. This comprehensive course addresses one of the most challenging areas in surgical pathology by integrating clinical findings, radiologic features, histopathology, immunohistochemistry, and molecular diagnostics into a unified diagnostic approach.

Designed for practicing pathologists, pathology trainees, and musculoskeletal pathology specialists, the course focuses on current diagnostic criteria, recent classification updates, and common pitfalls encountered when evaluating bone biopsies and resections.

Original Release Date: March 5, 2026
Format: 8 Videos + 12 PDFs
Publisher: USCAP
Language: English

Course Overview

Bone pathology remains one of the most diagnostically challenging subspecialties in surgical pathology. Accurate diagnosis often requires careful integration of histologic findings with clinical history, imaging studies, molecular testing, and contemporary classification systems.

This course provides a practical review of both benign and malignant bone lesions, including primary bone tumors, metastatic tumors, metabolic bone diseases, developmental disorders, inflammatory conditions, and trauma-related changes. Faculty emphasize real-world diagnostic strategies and provide guidance on avoiding common interpretive errors.

Special attention is given to applying the latest WHO terminology and incorporating emerging molecular and immunohistochemical techniques into daily practice.

Target Audience

This course is designed for:

Pathologists

• Surgical Pathologists

• Academic Pathologists

• Community Pathologists

• Musculoskeletal Pathologists

Trainees

• Pathology Residents

• Surgical Pathology Fellows

• Musculoskeletal Pathology Fellows

Other Healthcare Professionals

• Orthopedic Oncologists

• Bone Tumor Specialists

• Researchers in Musculoskeletal Disease

• Laboratory Professionals Supporting Bone Pathology

Learning Objectives

Upon completion of this activity, participants should be able to:

• Utilize the latest WHO terminology for primary bone tumors

• Apply updated diagnostic criteria for skeletal neoplasms

• Interpret immunohistochemical and molecular findings appropriately

• Diagnose common and uncommon non-neoplastic bone disorders

• Recognize major diagnostic pitfalls in bone pathology

• Correlate histologic findings with radiographic features

• Improve pathology reporting for bone lesions

• Understand the clinical implications of diagnostic findings

Neoplastic Bone Pathology

Primary Bone Tumors

Topics Covered

• Osteosarcoma

• Chondrosarcoma

• Ewing Sarcoma

• Osteoid Osteoma

• Osteoblastoma

• Giant Cell Tumor of Bone

• Fibrous Dysplasia

• Chondroblastoma

• Chondromyxoid Fibroma

Malignant Bone Neoplasms

Areas Covered

• High-Grade Osteosarcoma

• Conventional Chondrosarcoma

• Dedifferentiated Chondrosarcoma

• Small Round Blue Cell Tumors

• Undifferentiated Sarcomas

• Rare Bone Sarcomas

Metastatic Bone Disease

Topics Include

• Common Metastatic Tumors

• Differential Diagnosis

• Histopathologic Features

• Clinical Correlation

• Reporting Considerations

Non-Neoplastic Bone Pathology

Metabolic Bone Disorders

Topics Covered

• Osteoporosis

• Osteomalacia

• Hyperparathyroid Bone Disease

• Renal Osteodystrophy

• Metabolic Bone Changes

Developmental Bone Disorders

Areas Covered

• Skeletal Dysplasias

• Developmental Abnormalities

• Congenital Bone Disorders

• Diagnostic Challenges

Inflammatory Bone Conditions

Topics Include

• Osteomyelitis

• Chronic Inflammatory Disorders

• Reactive Changes

• Mimics of Neoplasia

Trauma-Related Bone Pathology

Areas Covered

• Fracture Healing

• Reactive Bone Changes

• Stress Injuries

• Post-Traumatic Remodeling

Histopathologic Evaluation

Morphologic Assessment

Topics Covered

• Key Histologic Features

• Tumor Pattern Recognition

• Differential Diagnosis

• Diagnostic Pearls

• Morphologic Mimics

Diagnostic Pitfalls

Areas Covered

• Common Misinterpretations

• Challenging Cases

• Overlapping Histology

• Strategies for Accurate Diagnosis

Radiologic-Pathologic Correlation

Integrated Diagnostic Approach

Topics Include

• Imaging Characteristics

• Bone Tumor Radiology

• Radiographic Differential Diagnosis

• Clinical Context in Interpretation

• Multidisciplinary Evaluation

Immunohistochemistry in Bone Pathology

Practical Applications

Topics Covered

• Marker Selection

• Diagnostic Algorithms

• Differential Diagnosis

• Interpretation Strategies

• Reporting Recommendations

Frequently Used Biomarkers

Areas Covered

• SATB2

• MDM2

• CDK4

• S100

• H3F3A-Related Markers

• Additional Diagnostic Markers

Molecular Pathology

Modern Diagnostic Testing

Topics Include

• Molecular Classification

• Gene Rearrangements

• Fusion Detection

• Molecular Biomarkers

• Next-Generation Sequencing

Clinical Utility

Areas Covered

• Diagnostic Confirmation

• Prognostic Assessment

• Therapeutic Implications

• Precision Medicine Applications

WHO Classification Updates

Current Terminology and Diagnostic Criteria

Topics Covered

• 2020 WHO Bone Tumor Classification

• Newly Defined Entities

• Updated Nomenclature

• Diagnostic Standards

• Emerging Concepts

Pathology Reporting

Clinically Relevant Reporting

Areas Covered

• Essential Reporting Elements

• Staging Considerations

• Margin Assessment

• Prognostic Information

• Multidisciplinary Communication

Case-Based Learning

Participants review numerous real-world examples including:

• Osteosarcoma Cases

• Chondrosarcoma Variants

• Ewing Sarcoma Diagnostics

• Benign Bone Tumors

• Metabolic Bone Disease

• Inflammatory Lesions

• Diagnostic Pitfalls

• Challenging Differential Diagnoses

Educational Highlights

Expert USCAP Faculty

Learn from internationally recognized specialists in bone and soft tissue pathology.

Practical Diagnostic Focus

Designed specifically for daily surgical pathology practice.

Integrated Learning Approach

Combines pathology, radiology, molecular diagnostics, and clinical correlation.

Case-Based Instruction

Real-world examples reinforce diagnostic principles and improve confidence.

Why This Course Stands Out

✔ Comprehensive Bone Pathology Review

✔ Neoplastic and Non-Neoplastic Disease Coverage

✔ WHO Classification Updates

✔ Advanced Molecular Pathology Applications

✔ Immunohistochemistry Interpretation

✔ Radiologic-Pathologic Correlation

✔ Diagnostic Pitfall Recognition

✔ Case-Based Learning

✔ Practical Reporting Guidance

✔ Evidence-Based Diagnostic Strategies

✔ Expert USCAP Faculty

✔ Applicable to Daily Surgical Pathology Practice

Who Should Take This Course?

Ideal for:

• Practicing Surgical Pathologists

• Academic Pathologists

• Community Pathologists

• Pathology Residents

• Surgical Pathology Fellows

• Musculoskeletal Pathology Specialists

• Orthopedic Oncology Teams

Clinical & Educational Value

The USCAP Practical Neoplastic and Non-Neoplastic Bone Pathology for the Surgical Pathologist 2026 provides a thorough and practical review of one of the most challenging areas in pathology. By integrating morphology, radiology, immunohistochemistry, molecular diagnostics, and contemporary WHO classifications, this course equips pathologists with the tools needed to confidently diagnose bone lesions and improve patient care.

+ Topics:

• Neoplastic and Non-Neoplastic Disorders – John D. Reith, MD
• Cartilaginous Tumors and Their Differentials – Darcy A. Kerr, MD
• Fibro-Osseous Lesions of the Craniofacial Skeleton and Their Differentials – Daniel Baumhoer, MD
• Neoplastic and Non-Neoplastic Disorders – G. Petur Nielsen, MD