Keck USC 13th Annual USC Multidisciplinary Breast Cancer Symposium 2026

The 13th Annual USC Multidisciplinary Breast Cancer Symposium brings surgical, medical, and radiation oncology perspectives together around current treatment decisions. The January 17, 2026 program at the SLS Hotel in Beverly Hills, California, examines ctDNA and artificial intelligence alongside antibody-drug conjugates, HER2-directed treatment, and endocrine therapy. Sessions also address management of the axilla, radiation for DCIS, fertility preservation, and breast cancer risk in gender-affirming care. Case presentations and moderated discussions connect these subjects across specialties. Presented by Keck USC, the symposium is relevant to clinicians who need to understand how diagnostic advances and systemic, surgical, and radiation treatments fit within multidisciplinary breast cancer care.

Learning Objectives

By the end of the course, participants will be able to:

• Understand the role of novel diagnostic tools for breast cancer including ctDNA and AI.
• Assess the risk of breast cancer in patients undergoing gender-affirming care.
• Explain the importance of fertility preservation during breast cancer treatment.
• Discuss appropriate use of ADCs and HER2-directed therapies.
• Identify the controversies regarding the role of radiation therapy in DCIS.
• Assess decision-making process in surgical management of the axilla.
• Incorporate the evolving role of clinical trials in radiation therapy.
• Define the role of neoadjuvant and novel endocrine therapy.
• Recognize an evolving role of Androgen and Glucocorticoid Receptors in breast cancer.

The original live symposium listed 7.25 AMA PRA Category 1 Credits; purchasing store files does not confer those credits. The agenda below includes scheduled cases and discussions and does not independently verify that each activity is included in the recordings.

Topics

• Welcome and Opening Remarks (Eric L. Chang, MD and Lajos Pusztai, MD, D.Phil)

• Session I (Moderator: Jason C. Ye, MD)

  • ctDNA for Breast Cancer (Lajos Pusztai, MD, D.Phil)

  • Evolving Use of Artificial Intelligence for Breast Cancer Detection and Diagnosis (Mary Yamashita, MD)

  • Case Presentation and Discussion (Claire Valburg, MD)

  • Breast Cancer Risk in Patients Undergoing Gender Affirming Surgery (Emily L. Siegel, MD)

  • Case Presentation and Discussion (Seyi Omeh, MD)

  • Fertility Considerations in Breast Cancer Patients (Katherine McDaniel, MD)

  • Case Presentation and Discussion (Amanda Daoud, DO)

• Break

• Session II (Moderator: Daphne Stewart, MD, MS)

  • Biomarkers for Antibody-Drug Conjugates (Samer Alkassis, MD, MS)

  • Update on HER2+-Directed Therapy in Early Breast Cancer (Charles E. Geyer, Jr., MD)

  • Case Presentation and Discussion (Krithika Chennapan, MD)

• Lunch

• Session III (Moderator: Eric L. Chang, MD)

  • Radiation Therapy I – Radiation Therapy for DCIS (Chirag Shah, MD)

  • Who Still Needs Surgical Staging of the Axilla? (Stephen F. Sener, MD)

  • Radiation Therapy II – Role of Regional Node Irradiation: NSABP B-51 (Jason C. Ye, MD)

  • Case Presentation and Discussion (Stephen F. Sener, MD)

• Break

• Session IV (Moderator: Stephen F. Sener, MD)

  • Neoadjuvant Endocrine Therapy (Kelly Hunt, MD)

  • Evolving Role of Androgen and Glucocorticoid Receptors in Breast Cancer (Gini Fleming, MD)

  • Novel Endocrine Agents in Development: Downregulating the Estrogen Receptor (William J. Gradishar, MD)

  • Case Presentation and Discussion (Sara Cartwright, DO)

• Closing Remarks & Adjourn