Columbia University C3G & Immune Complex MPGN Updates 2026

Columbia University’s C3G and Immune Complex MPGN Updates 2026 brings together nephrology, renal pathology, and infectious disease perspectives on complement-mediated kidney injury. The October 2 virtual program moves from complement biology and disease mechanisms to clinical recognition, biopsy interpretation, complement panels, and genetic testing. Later sessions consider evolving treatment approaches, infection-risk mitigation during complement-targeted therapy, and multidisciplinary cases. Directed by Andrew S. Bomback, MD, MPH, and Jai Radhakrishnan, MD, MS, the course is intended for nephrologists, renal pathologists, fellows, and researchers reviewing these uncommon glomerular disorders. The original agenda runs from 8:25 AM to 2:00 PM Eastern Time.

Learning Objectives

Upon completion of this educational activity, participants should be able to:

1. Describe the distinct mechanisms underlying C3G and IC-MPGN, focusing on how complement dysregulation and immune complex deposition lead to these diseases.

2. Identify genetic and acquired disruptions in complement regulation and their impact on glomerular function in C3G and IC-MPGN.

3. Discuss recent therapeutic advances targeting complement dysregulation, like iptacopan and pegcetacoplan, and their potential in modifying disease progression.

4. Differentiate primary IC-MPGN from secondary forms associated with systemic diseases, and identify diagnostic criteria for distinguishing these subtypes.

5. Recognize the specific biopsy findings, complement assays, and genetic tests that aid in diagnosing C3G and IC GN.

6. Discuss the prevalence, risk factors, and demographic characteristics associated with C3G and IC-MPGN.

Program scope: The Topics below reproduce the original live conference agenda and do not independently verify which recordings are included in this product. The original activity’s 5.5-credit designation does not confer credit or certification with separately distributed files.

+ Topics:

• 8:25 Welcome & Introductions Course Directors: Jai Radhakrishnan MD, MS; Andrew S. Bomback MD, MPH
• SESSION 1: MECHANISMS DRIVING COMPLEMENT-MEDIATED GLOMERULAR INJURY
• 8:30 Complement Biology in the Modern Era: From Pathways to Therapeutic Targets Benjamin Wooden MD, Assistant Professor of Medicine, Nephrology, Columbia
• 9:00 Integrated Mechanisms of Injury in C3 Glomerulopathy & Immune Complex MPGN Mariela Navarro-Torres MD, Assistant Professor of Medicine, Nephrology, Columbia
• 9:30 Q&A
• SESSION 2: CONTEMPORARY APPROACHES TO DIAGNOSING COMPLEMENT-MEDIATED GN
• 10:00 Clinical Clues and Early Recognition of C3 Glomerulopathy & Immune Complex-Mediated MPGN Jai Radhakrishnan MD, MS, Professor of Medicine, Nephrology, Columbia
• 10:35 Pathologic Patterns & Biopsy Interpretation in Complement-Driven GN Dominick Santoriello MD, Associate Professor of Pathology & Cell Biology, Columbia
• 11:10 C3 Glomerulopathy and IC-MPGN Advanced Diagnostic Tools: Complement Panels, Genetics & Beyond Andrew S. Bomback MD, MPH, Associate Professor of Medicine, Nephrology, Columbia
• 11:45 Q&A
• SESSION 3: MANAGEMENT, INFECTIOUS RISK & THERAPEUTIC DECISION-MAKING
• 12:00 Evolving Treatment Paradigms: Precision Approaches to C3 Glomerulopathy & Immune Complex MPGN Andrew S. Bomback MD, MPH, Associate Professor of Medicine, Nephrology, Columbia
• 12:30 Infectious Disease Risk Mitigation in Complement-Targeted Therapy Marcus Pereira MD, MPH, Professor of Medicine, Infectious Diseases, Columbia
• 1:00 Challenging Clinical Scenarios: Multidisciplinary Case Discussions Miroslav Sekulic MD, Associate. Professor of Pathology & Cell Biology, Columbia Natasha Freeman MD, MS, Assistant Professor of Medicine, Nephrology, Columbia
• 1:30 Q&A
• 2:00 Adjourn