Columbia University C3G & Immune Complex MPGN Updates 2026

Columbia University C3G & Immune Complex MPGN Updates 2026 is an advanced, evidence-based nephrology educational conference focused on the latest developments in C3 glomerulopathy (C3G) and immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN), including complement pathway dysregulation, renal pathology, genetic testing, diagnostic advances, and emerging targeted therapies.

Presented by Columbia University Medical Center, this specialized 2026 program brings together experts in nephrology, renal pathology, and infectious diseases to explore challenging clinical scenarios and contemporary approaches to rare glomerular diseases.

The course emphasizes the clinical application of complement biology, precision medicine, renal biopsy interpretation, and complement-targeted treatments, including discussions relevant to iptacopan and pegcetacoplan.

Through expert lectures, case-based presentations, multidisciplinary discussions, and interactive Q&A sessions, participants gain practical insights into the diagnosis and management of complement-mediated glomerular disorders.

Course Details

The original live conference was designated for a maximum of 5.5 AMA PRA Category 1 Credits™. This does not establish eligibility for CME credits or a certificate from a separately distributed recording.

Target Audience

This course is designed for healthcare professionals and researchers involved in the diagnosis, treatment, and investigation of rare glomerular disorders.

• Nephrologists and renal specialists managing C3 glomerulopathy, IC-MPGN, and other complement-mediated kidney diseases.

• Renal pathologists interpreting glomerular biopsy findings and complex patterns of immune and complement deposition.

• Internal medicine physicians interested in kidney disorders and systemic diseases associated with glomerulonephritis.

• Nephrology and pathology fellows seeking advanced training in glomerular disease diagnosis and management.

• Clinical researchers and scientists investigating complement biology, genetic variants, and immune-mediated kidney injury.

• Pharmacologists and therapeutic researchers studying complement inhibitors and novel disease-modifying therapies.

• Other healthcare professionals involved in multidisciplinary kidney disease management.

Program Overview

C3 glomerulopathy and immune complex-mediated membranoproliferative glomerulonephritis are uncommon, clinically challenging disorders characterized by complex interactions among complement activation, immune mechanisms, genetic susceptibility, and glomerular injury.

Advances in complement biology and diagnostic technologies have transformed the understanding of these diseases, creating opportunities for more precise diagnostic evaluation and targeted therapeutic intervention.

The Columbia University C3G & Immune Complex MPGN Updates 2026 conference examines the mechanisms underlying complement-mediated glomerular injury and their implications for contemporary clinical practice.

The program addresses important developments in:

• Complement pathway biology and dysregulation

• C3 glomerulopathy pathogenesis and genetic susceptibility

• Immune complex-mediated glomerular injury

• Renal biopsy interpretation and pathological classification

• Complement assays and advanced genetic diagnostics

• Primary versus secondary IC-MPGN

• Precision treatment approaches and emerging complement inhibitors

• Infectious complications and risk mitigation during complement-targeted therapy

• Multidisciplinary decision-making in complex glomerular disease

The educational format combines expert presentations, evidence-based discussions, and clinically relevant case studies to support the translation of emerging scientific knowledge into patient care.

Learning Objectives

Upon completion of this educational activity, participants should be able to:

1. Describe the distinct mechanisms underlying C3G and IC-MPGN, focusing on how complement dysregulation and immune complex deposition lead to these diseases.

2. Identify genetic and acquired disruptions in complement regulation and their impact on glomerular function in C3G and IC-MPGN.

3. Discuss recent therapeutic advances targeting complement dysregulation, like iptacopan and pegcetacoplan, and their potential in modifying disease progression.

4. Differentiate primary IC-MPGN from secondary forms associated with systemic diseases, and identify diagnostic criteria for distinguishing these subtypes.

5. Recognize the specific biopsy findings, complement assays, and genetic tests that aid in diagnosing C3G and IC GN.

6. Discuss the prevalence, risk factors, and demographic characteristics associated with C3G and IC-MPGN.

These six objectives follow the published Columbia University course objectives.

Official Program Topics and Faculty

The following session titles, presentation times, and speakers are taken from the published October 2026 conference agenda. Official Columbia University conference program.

Opening Session

8:25 AM — Welcome & Introductions

Course Directors:

• Jai Radhakrishnan, MD, MS

• Andrew S. Bomback, MD, MPH

Session 1: Mechanisms Driving Complement-Mediated Glomerular Injury

8:30 AM — Complement Biology in the Modern Era: From Pathways to Therapeutic Targets

Speaker: Benjamin Wooden, MD

Assistant Professor of Medicine, Nephrology, Columbia University.

9:00 AM — Integrated Mechanisms of Injury in C3 Glomerulopathy & Immune Complex MPGN

Speaker: Mariela Navarro-Torres, MD

Assistant Professor of Medicine, Nephrology, Columbia University.

9:30 AM — Q&A

Session 2: Contemporary Approaches to Diagnosing Complement-Mediated GN

10:00 AM — Clinical Clues and Early Recognition of C3 Glomerulopathy & Immune Complex-Mediated MPGN

Speaker: Jai Radhakrishnan, MD, MS

Professor of Medicine, Nephrology, Columbia University.

10:35 AM — Pathologic Patterns & Biopsy Interpretation in Complement-Driven GN

Speaker: Dominick Santoriello, MD

Associate Professor of Pathology & Cell Biology, Columbia University.

11:10 AM — C3 Glomerulopathy and IC-MPGN Advanced Diagnostic Tools: Complement Panels, Genetics & Beyond

Speaker: Andrew S. Bomback, MD, MPH

Associate Professor of Medicine, Nephrology, Columbia University.

11:45 AM — Q&A

Session 3: Management, Infectious Risk & Therapeutic Decision-Making

12:00 PM — Evolving Treatment Paradigms: Precision Approaches to C3 Glomerulopathy & Immune Complex MPGN

Speaker: Andrew S. Bomback, MD, MPH

Associate Professor of Medicine, Nephrology, Columbia University.

12:30 PM — Infectious Disease Risk Mitigation in Complement-Targeted Therapy

Speaker: Marcus Pereira, MD, MPH

Professor of Medicine, Infectious Diseases, Columbia University.

1:00 PM — Challenging Clinical Scenarios: Multidisciplinary Case Discussions

Speakers:

• Miroslav Sekulic, MD — Associate Professor of Pathology & Cell Biology, Columbia University.

• Natasha Freeman, MD, MS — Assistant Professor of Medicine, Nephrology, Columbia University.

1:30 PM — Q&A

2:00 PM — Adjourn

Source: Official conference agenda published by Columbia Medicine CME. The agenda identifies the original live sessions; it does not independently verify which recordings are included in a commercial product.

Major Topics Covered

1. C3 Glomerulopathy and Complement Dysregulation

The course explores the molecular and immunological mechanisms responsible for C3 glomerulopathy, emphasizing the alternative complement pathway and the consequences of abnormal complement regulation.

Key areas include complement activation, acquired and genetic abnormalities, glomerular inflammation, and the relationship between complement dysregulation and progressive kidney injury.

2. Immune Complex-Mediated MPGN

Educational discussions examine immune complex-mediated membranoproliferative glomerulonephritis, its underlying mechanisms, and its distinction from C3G.

Special attention is given to identifying primary and secondary disease processes and understanding the role of systemic conditions in immune complex deposition.

3. Renal Pathology and Biopsy Interpretation

Renal biopsy evaluation is central to the diagnosis and classification of glomerular diseases.

The program addresses pathological patterns of complement-mediated injury, glomerular immune deposits, and the integration of biopsy findings with clinical and laboratory data.

4. Genetic Testing and Complement Biomarkers

Advances in complement assays and genetic testing offer opportunities for more detailed disease characterization.

Topics include inherited and acquired abnormalities in complement regulation, interpretation of complement studies, and the clinical value of specialized diagnostic investigations.

5. Emerging Complement-Targeted Therapies

The course explores contemporary and evolving treatment strategies in complement-mediated kidney diseases.

Therapeutic discussions include the role of targeted complement inhibition, precision approaches to glomerular disease, and emerging treatments such as iptacopan and pegcetacoplan.

6. Infectious Risk and Treatment Safety

Because complement-targeted therapies may alter immune defense mechanisms, the conference includes a dedicated discussion of infectious disease risk mitigation.

This component emphasizes the importance of assessing treatment-related infectious complications and incorporating risk-reduction strategies into therapeutic decision-making.

7. Challenging Clinical Cases

Multidisciplinary case discussions bring together nephrology, pathology, and related expertise to examine complex diagnostic and management scenarios.

Participants are encouraged to integrate clinical presentations, laboratory findings, pathology results, and therapeutic considerations into evidence-based decisions.

Course Directors

Featured Faculty

• Benjamin Wooden, MD — Nephrology, Columbia University

• Mariela Navarro-Torres, MD — Nephrology, Columbia University

• Dominick Santoriello, MD — Pathology & Cell Biology, Columbia University

• Marcus Pereira, MD, MPH — Infectious Diseases, Columbia University

• Miroslav Sekulic, MD, MS — Pathology & Cell Biology, Columbia University

• Natasha Freeman, MD, MS — Nephrology, Columbia University

Faculty and course-director information is confirmed by the official event organizer.

Why This Course Is Relevant

The Columbia University C3G & Immune Complex MPGN Updates 2026 conference provides a specialized learning opportunity for clinicians working with uncommon and diagnostically challenging glomerular disorders.

The program stands out through its focused coverage of complement biology, advanced renal diagnostics, emerging targeted treatments, and multidisciplinary case interpretation.

Its integration of nephrology, renal pathology, and infectious diseases helps connect molecular mechanisms with real-world clinical management.

For nephrologists, pathology specialists, and clinical researchers, this educational resource offers a clinically relevant overview of the evolving diagnosis and treatment of complement-mediated glomerular disease.

Short Description

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+ Topics:

• 8:25 Welcome & Introductions Course Directors: Jai Radhakrishnan MD, MS; Andrew S. Bomback MD, MPH
• SESSION 1: MECHANISMS DRIVING COMPLEMENT-MEDIATED GLOMERULAR INJURY
• 8:30 Complement Biology in the Modern Era: From Pathways to Therapeutic Targets Benjamin Wooden MD, Assistant Professor of Medicine, Nephrology, Columbia
• 9:00 Integrated Mechanisms of Injury in C3 Glomerulopathy & Immune Complex MPGN Mariela Navarro-Torres MD, Assistant Professor of Medicine, Nephrology, Columbia
• 9:30 Q&A
• SESSION 2: CONTEMPORARY APPROACHES TO DIAGNOSING COMPLEMENT-MEDIATED GN
• 10:00 Clinical Clues and Early Recognition of C3 Glomerulopathy & Immune Complex-Mediated MPGN Jai Radhakrishnan MD, MS, Professor of Medicine, Nephrology, Columbia
• 10:35 Pathologic Patterns & Biopsy Interpretation in Complement-Driven GN Dominick Santoriello MD, Associate Professor of Pathology & Cell Biology, Columbia
• 11:10 C3 Glomerulopathy and IC-MPGN Advanced Diagnostic Tools: Complement Panels, Genetics & Beyond Andrew S. Bomback MD, MPH, Associate Professor of Medicine, Nephrology, Columbia
• 11:45 Q&A
• SESSION 3: MANAGEMENT, INFECTIOUS RISK & THERAPEUTIC DECISION-MAKING
• 12:00 Evolving Treatment Paradigms: Precision Approaches to C3 Glomerulopathy & Immune Complex MPGN Andrew S. Bomback MD, MPH, Associate Professor of Medicine, Nephrology, Columbia
• 12:30 Infectious Disease Risk Mitigation in Complement-Targeted Therapy Marcus Pereira MD, MPH, Professor of Medicine, Infectious Diseases, Columbia
• 1:00 Challenging Clinical Scenarios: Multidisciplinary Case Discussions Miroslav Sekulic MD, Associate. Professor of Pathology & Cell Biology, Columbia Natasha Freeman MD, MS, Assistant Professor of Medicine, Nephrology, Columbia
• 1:30 Q&A
• 2:00 Adjourn